That would be the hard drive, typically on the primary drive if the computer has more than one hard drive. On a Windows PC that's (as was mentioned by another responder) the C: Drive. On a Mac OS X or Linux computer the drive would have a different label, but it's the same idea.
This video on YouTube gives a great & simple explanation of what a hard drive is.
This video on YouTube gives a great & simple explanation of what a hard drive is.