I use wired. I have a wireless setup but don't like it, there seems to be some lag time.
Since I'm left handed, I use the wireless set-up. Much easier with no wire to drag around. Key board and mouse.
I have two computers on my desk---one with Win 7, one with Win 10.
I had wireless on my Win 7, but I use the wired mouse and keyboard on my Win 10.
I like my systems to be individually dedicated and it's easy to put the wireless I/O's to the side until I need them.
I use wired.